Characterisation of curcumin‐loaded proliposomes produced by coating of micronised sucrose and hydration of phospholipid powders to obtain multilamellar liposomes

• Published in: International journal of food science & technology Vol. 52; no. 3; pp. 772 - 780
• Main Authors: Silva, Guilherme S., Jange, Camila G., Rocha, Juliana S.S., Chaves, Matheus A., Pinho, Samantha C.
• Format: Journal Article
• Language: English
• Published: Oxford Wiley Subscription Services, Inc 01.03.2017
• Subjects: Bioavailability; Chromium; Coating; Curcuminoid; Dispersions; encapsulation; Food science; Hydration; Lipids; liposome production; Liposomes; phospholipid vesicles; Phospholipids; Spices; Sucrose
• ISSN: 0950-5423; 1365-2621
• DOI: 10.1111/ijfs.13334

Summary The objective of this study was to obtain and characterise curcumin‐loaded proliposomes by the method of coating of micronised sucrose. Proliposomes incorporating curcumin were characterised in terms of coating, morphology, crystallinity, solubility and water sorption. The powders showed a good capacity to preserve curcumin, as after 60 days of storage about 80% of the initial amount of curcumin was preserved. The water adsorption on the proliposomes was very low, as was the hygroscopicity (3.4%). The evaluation of the capacity of the multilamellar liposomes produced by the hydration of phospholipid powders to preserve encapsulated curcumin was assessed. Liposome dispersions were produced with different thickeners, and the best results of average size (around 800 nm) and curcumin preservation (72% after 30 days of storage) were obtained with xanthan gum and guar gum. These results evidenced the coating of micronised sucrose is a promising technique to produce liposomes to be incorporated into food. The objective of this study was to obtain and characterize curcumin‐loaded proliposomes by the method of coating of micronised sucrose. The use of lipid formulations can increase the bioaccessibility of this natural yellow pigment, The results show it is possible to produce proliposomes incorporating curcumin by a scalable method, free of harmful organic solvents, and the results can be used for further improvement of the process and for the enhancement of the liposomes? stability.