Human midbrain dopaminergic progenitors

• Published in: Cell proliferation Vol. 57; no. 4; pp. e13563 - n/a
• Main Authors: Wang, Yu‐Kai, Feng, Lin, Ma, Ai‐Jin, Hao, Jie, Zhang, Ying, Chen, Yue‐Jun, Chen, Zhi‐Guo, Yu, Jun‐Ying, Liu, Yan, Liu, Chang‐Mei, Zhang, Yu, Wang, Chang‐Lin, Teng, Zhao‐Qian, Zhou, Jia‐Xi, Li, Tian‐Qing, Wang, Liu, Fu, Bo‐Qiang, Fu, Yu Vincent, Zhu, Li‐Jun, Liang, Ling‐Min, Cao, Jia‐Ni, Wang, Lei, Zhou, Qi, Xiang, Andy Peng, Hu, Bao‐Yang, Zhao, Tong‐Biao
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2024; John Wiley and Sons Inc
• Subjects: Acids; Cells; China; Cryopreservation; Cytomegalovirus; Dopamine; Dopamine receptors; Dopaminergic Neurons - metabolism; Epstein-Barr virus; Hepatitis B; Hepatitis C; HIV; Human immunodeficiency virus; Humans; Immune system; Informed consent; International standards; Labeling; Medical laboratories; Mesencephalon; Microorganisms; Morphology; Packaging; Practice Insights; Process controls; Quality control; Quality management; Quality standards; Raw materials; Standardization; Stem cells; Storage requirements; Test methods; Therapeutic applications; Waste disposal; China
• ISSN: 0960-7722; 1365-2184
• DOI: 10.1111/cpr.13563

Human midbrain dopaminergic progenitors (mDAPs) are one of the most representative cell types in both basic research and clinical applications. However, there are still many challenges for the preparation and quality control of mDAPs, such as the lack of standards. Therefore, the establishment of critical quality attributes and technical specifications for mDAPs is largely needed. “Human midbrain dopaminergic progenitor” jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human mDAPs in China. This standard specifies the technical requirements, test methods, inspection rules, instructions for usage, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for human mDAPs, which is applicable to the quality control for human mDAPs. It was originally released by the China Society for Cell Biology on 30 August 2022. We hope that the publication of this guideline will facilitate the institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of human mDAPs for clinical development and therapeutic applications.