Conduction block in neuropathies with necrotizing vasculitis

Thirty-two patients with a mononeuropathy multiplex associated with a systemic necrotizing vasculitis were studied. The main abnormality was a loss of motor and sensory axons confirmed by electrophysiological and histological methods. A conduction block was observed in five patients, but only one wa...

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Bibliographic Details
Published inMuscle & nerve Vol. 13; no. 2; p. 102
Main Authors Ropert, A, Metral, S
Format Journal Article
LanguageEnglish
Published United States 01.02.1990
Subjects
Adult
Aged
Aged, 80 and over
Blood Vessels
Electrophysiology
Female
Humans
Infarction - diagnosis
Infarction - physiopathology
Ischemia - diagnosis
Ischemia - physiopathology
Male
Middle Aged
Neural Inhibition - physiology
Polyarteritis Nodosa - diagnosis
Polyarteritis Nodosa - physiopathology
Retrospective Studies
Vasa Nervorum
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Summary:Thirty-two patients with a mononeuropathy multiplex associated with a systemic necrotizing vasculitis were studied. The main abnormality was a loss of motor and sensory axons confirmed by electrophysiological and histological methods. A conduction block was observed in five patients, but only one was at a usual site of compression. Based on previous pathological studies and the experimental data in human and animals, the mechanism of the block is proposed to be ischemic. It is suggested that a conduction block in one nerve in a neuropathy with two or more individual nerves affected and with electrophysiological features of axonal degeneration may be due to a vasculitis.
ISSN:0148-639X
DOI:10.1002/mus.880130203