Peri‐Implant Epstein–Barr Virus (+) Mucocutaneous Ulcer in an Immunocompetent Patient: Case Report and Review of the Literature

• Published in: Clinical implant dentistry and related research Vol. 27; no. 1; pp. e13440 - n/a
• Main Authors: Lafuente‐Ibáñez de Mendoza, Irene, Aguirre‐Echevarria, Pablo, Silva‐Soria, Tulio Mateo, Aisa, Francisco Javier Vallejo, Larrinoa, Aitor Fernández, Aguirre‐Urizar, José Manuel
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2025; Wiley Subscription Services, Inc
• Subjects: Aged, 80 and over; Case Report; CD20 antigen; CD3 antigen; CD30 antigen; Dental Implants; Epstein-Barr virus; Epstein-Barr Virus Infections - diagnosis; Herpesvirus 4, Human - isolation & purification; histological analysis; Humans; Immunocompetence; Immunocompromised hosts; Immunosenescence; implant; Lesions; Literature reviews; Lymphocytes; Male; Mouth Mucosa - pathology; Mouth Mucosa - virology; Mucosa; Oral Ulcer - pathology; Oral Ulcer - virology; implant; case report; histological analysis
• ISSN: 1523-0899; 1708-8208; 1708-8208
• DOI: 10.1111/cid.13440

ABSTRACT Epstein–Barr virus (+) mucocutaneous ulcer (EBVMCU) is an uncommon benign lymphoproliferative lesion that develops in immunocompromised patients. We present a special case of EBVMCU located in the peri‐implant mucosa and we review the oral cases published to date. An 88‐year‐old man with no medical history of interest was attended in the dental clinic due to an ulcerated tumor located in the peri‐implant mucosa. The lesion showed an atypical lymphoid proliferation, positive for CD3, CD20, CD30, PAX‐5, and MUM1. Positive EBV and favorable patient evolution confirmed the final diagnosis of EBVMCU. Oral EBVMCU reports related to immunosenescence mainly develop in the gingiva of advanced age patients. Our case highlights the importance to perform a complete clinicopathological study of all peri‐implant lesions. Although most peri‐implant pathologies are inflammatory‐reactive disorders, sometimes they can also correspond to other entities.