Affective neuroscience personality traits in opioid use disorder patients: The relationship with earlier onset of substance use, the severity of addiction, and motivational factors to quit opiate use

• Published in: Brain and behavior Vol. 14; no. 9; pp. e70050 - n/a
• Main Authors: Aşut, Gonca, Alıcı, Yasemin Hoşgören, Ceran, Selvi, Danışman, Mustafa, Şahiner, Şafak Yalçın
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.09.2024; John Wiley and Sons Inc; Wiley
• Subjects: Addictions; Adult; affective personality; Age of Onset; ANGER; Behavior, Addictive - physiopathology; Chronic illnesses; Drug use; early onset drug use; Emotions; Female; Humans; Hypotheses; Male; Mental disorders; Middle Aged; Motivation; Motivation - physiology; Narcotics; Neurosciences; opioid addiction; Opioid-Related Disorders - physiopathology; Opioid-Related Disorders - psychology; Original; Personality; Personality - physiology; Personality traits; Risk Factors; Severity of Illness Index; Sociodemographics; Substance use disorder; Young Adult; early onset drug use; affective personality; ANGER; opioid addiction
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.70050

Introduction This study aims to explore the relationship between affective personality traits and opioid use disorder (OUD), including factors such as motivation to quit, addiction severity, and age of onset of drug use. Methods This study included 141 patients with opioid addiction (OAP) and 160 age‐ and sex‐matched healthy controls (HC). OAP were interviewed and diagnosed according to DSM‐5 criteria. HC were screened for past or current drug use. Participants completed sociodemographic forms and the Affective Neuroscience Personality Scale (ANPS), and the OAP group also completed the Addiction Profile Index (API). Results SEEK, PLAY, and SADNESS were identified as different affective personality traits between OAP and HC groups. Addiction severity was positively correlated with SADNESS and ANGER, while the age of onset of drug use was correlated with ANGER. Risk factors for OA include family history of substance abuse, low education, and low PLAY scores, whereas risk factors for earlier substance use onset are childhood trauma and high ANGER scores. Conclusions This study highlights the importance of understanding affective personality traits in OUD. These findings may deepen our understanding of the underlying mechanisms of OUD. The identification of these affective systems may have implications for the development of personalized prevention and treatment strategies.