A Case-Control Study in IL6 and TGFB1 Gene Polymorphisms and Recurrent Spontaneous Abortion in Southern Brazilian Patients
Problem: A high proportion of recurrent spontaneous abortions (RSA) remains unexplained. Cytokine genotyping has been investigated. We studied the relationship between unexplained RSA, IL6 (−174 G→C) and TGFB1 (+869, T→C; +915, G→C) gene polymorphisms. Method of Study: The case–control study compo...
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Published in | American journal of reproductive immunology (1989) Vol. 53; no. 2; pp. 94 - 99 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2005
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Subjects | |
Online Access | Get full text |
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Summary: | Problem: A high proportion of recurrent spontaneous abortions (RSA) remains unexplained. Cytokine genotyping has been investigated. We studied the relationship between unexplained RSA, IL6 (−174 G→C) and TGFB1 (+869, T→C; +915, G→C) gene polymorphisms.
Method of Study: The case–control study composed of 57 south Brazilian women, with unexplained RSA and 74 controls carefully matched was performed. Cytokine genotyping was performed by the polymerase chain reaction–sequence specific primer method, using the ‘Cytokine Genotyping Tray’.
Results: The results showed that the genotypic frequencies did not differ from samples for TGFB1 gene. In relation to IL6 gene polymorphism there was a statistical difference in genotypic distribution between samples (P ≤ 0.025). The frequency of the C/C genotype was increased in women with RSA in comparison with the frequency observed in controls: 18% versus 4% (P = 0.01).
Conclusions: This result strengthened the importance of IL6 genotypes in the pathogenesis of RSA of unknown cause in the south Brazilian population. |
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Bibliography: | ark:/67375/WNG-V16999JS-C istex:571F55B4C8BDB3B89ADDC8C9064A20673CB358CD ArticleID:AJI250 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1046-7408 1600-0897 |
DOI: | 10.1111/j.1600-0897.2005.00250.x |