A Single Nucleotide Polymorphism in GAS5 lncRNA is Associated with Risk of Bladder Cancer in Iranian Population

• Published in: Pathology oncology research Vol. 26; no. 2; pp. 1251 - 1254
• Main Authors: Rakhshan, Azadeh, Esmaeili, Mohammad Hossein, Kahaei, Mir Salar, Taheri, Mohammad, Omrani, Mir Davood, Noroozi, Rezvan, Ghafouri-Fard, Soudeh
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2020; Springer Nature B.V
• Subjects: Adult; Aged; Biomedical and Life Sciences; Biomedicine; Bladder cancer; Cancer; Cancer Research; Carcinoma, Transitional Cell - genetics; Case-Control Studies; Female; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes; Health risk assessment; Heredity; Humans; Immunology; Iran; Male; Middle Aged; Non-coding RNA; Oncology; Original Article; Pathology; Polymorphism, Single Nucleotide; RNA, Long Noncoding - genetics; Single-nucleotide polymorphism; Urinary Bladder Neoplasms - genetics; Iran; Bladder cancer; lncRNA; GAS5
• ISSN: 1219-4956; 1532-2807; 1532-2807
• DOI: 10.1007/s12253-019-00693-2

Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 ( GAS5 ) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27–5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18–2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.