High intensity focused ultrasound for the treatment of rat tumours

Discrete implanted liver tumours in the rat have been exposed to arrays of 1.7 MHz ultrasound lesions. Focal peak intensities in the range 1.4-3.5 k Wcm-2 were used for an exposure time of 10 s. It has been demonstrated that where the whole tumour volume was exposed to the focused ultrasound beam, n...

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Bibliographic Details
Published inPhysics in medicine & biology Vol. 36; no. 11; pp. 1495 - 1501
Main Authors Haar, G ter, Rivens, I, Chen, L, Riddler, S
Format Journal Article Conference Proceeding
LanguageEnglish
Published Bristol IOP Publishing 01.11.1991
Institute of Physics
Subjects
Animals
Biological and medical sciences
Female
Fibrosarcoma - therapy
Medical sciences
Neoplasm Transplantation
Rats
Rats, Inbred Strains
Treatment with physical agents
Treatment. General aspects
Tumors
Ultrasonic Therapy
Sonography
Treatment
Animal
Digestive diseases
Hepatic disease
Tumor
Experimental study
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Summary:Discrete implanted liver tumours in the rat have been exposed to arrays of 1.7 MHz ultrasound lesions. Focal peak intensities in the range 1.4-3.5 k Wcm-2 were used for an exposure time of 10 s. It has been demonstrated that where the whole tumour volume was exposed to the focused ultrasound beam, no evidence of tumour growth could be detected histologically. Where the ultrasonic lesion array was not contiguous, regrowth occurred. Preliminary histological studies confirmed this finding.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/36/11/009