Role of the E3 Ubiquitin Ligase TRIM4 in Predicting the Prognosis of Hepatocellular Carcinoma

The E3 ubiquitin ligase TRIM4 has been reported to regulate the assembly of the antiviral signalling complex, induce mitochondrial aggregation and sensitize cells to H O -induced death. However, the relationship between TRIM4 and human malignancies, including hepatocellular carcinoma (HCC), is uncle...

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Published inJournal of Cancer Vol. 11; no. 14; pp. 4007 - 4014
Main Authors Dong, Zhao-Ru, Zhou, Wei, Sun, Dong, Yan, Yu-Chuan, Yang, Chun-Cheng, Yang, Ya-Fei, Li, Hai-Chao, Zhi, Xu-Ting, Li, Tao
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2020
Ivyspring International Publisher
Subjects
Antibodies
Cell cycle
Enzymes
Liver cancer
Medical prognosis
Patients
Proteins
Research Paper
Statistical analysis
Tumorigenesis
Tumors
progression
E3 ubiquitin ligase
TRIM4
hepatocellular carcinoma
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Summary:The E3 ubiquitin ligase TRIM4 has been reported to regulate the assembly of the antiviral signalling complex, induce mitochondrial aggregation and sensitize cells to H O -induced death. However, the relationship between TRIM4 and human malignancies, including hepatocellular carcinoma (HCC), is unclear. In this study, we detected the expression of TRIM4 in 134 pairs of HCC tissues and peritumoural tissues and investigated the association of TRIM4 expression with the prognosis of HCC. We found that the TRIM4 expression was much lower in HCC tissues than in peritumoural tissues and was significantly associated with vascular invasion, tumour capsule and Hong Kong Liver Cancer (HKLC) stage. Univariate and multivariate analyses revealed that the TRIM4 expression was an independent prognostic factor for overall survival (OS) and recurrence-free survival (RFS) in our HCC cohort. Patients with higher TRIM4 expression had a lower incidence of intrahepatic recurrence and a higher OS rate ( <0.001 and <0.01, respectively). These results were further validated in another independent cohort of 200 HCC patients. In conclusion, the TRIM4 level in HCC tissues is an independent prognostic factor for HCC patients. Close clinical monitoring is recommended for patients with low TRIM4 expression.
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Competing Interests: The authors have declared that no competing interest exists.
Those authors contributed equally to this work.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.37164