The initial presentation of systemic lupus erythematosis with aplastic anemia successfully treated with rituximab

Hematologic disorders are common in autoimmune diseases. First presentation of systemic lupus erythematosis with aplastic anemia is extremely rare. We report a patient with the diagnosis of secondary aplastic anemia associated with lupus. All routine medications were not effective. She received Ritu...

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Published inClinical rheumatology Vol. 31; no. 2; pp. 381 - 384
Main Authors Alishiri, Gholam-Hossein, Saburi, Amin, Bayat, Noushin, Saadat, Ali-Reza, Saburi, Ehsan
Format Journal Article
LanguageEnglish
Published London Springer-Verlag 01.02.2012
Springer Nature B.V
Subjects
Adult
Anemia, Aplastic - etiology
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Antirheumatic Agents - therapeutic use
Aplastic anemia
Autoimmune diseases
Case Based Review
Drugs
Female
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - drug therapy
Medicine
Medicine & Public Health
Rheumatology
Rituximab
Treatment Outcome
Rituximab
Pancytopenia
Aplastic anemia
Biologic therapy
Systemic lupus erythematosis
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Summary:Hematologic disorders are common in autoimmune diseases. First presentation of systemic lupus erythematosis with aplastic anemia is extremely rare. We report a patient with the diagnosis of secondary aplastic anemia associated with lupus. All routine medications were not effective. She received Rituximab and her response was satisfactory. Her hematologic parameters were within normal range until last follow-up, six months after therapy was initiated with Rituximab. Review of literature displayed 23 cases of acquired aplastic anemia secondary to systemic lupus erythematosis; however, this is the first time the new drug therapy was used for the treatment.
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ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-011-1878-z