Recent advances in ultra-small fluorescent Au nanoclusters toward oncological research
Au nanoclusters possess a series of excellent properties owing to their size being comparable to the Fermi wavelength of electrons. For example, they show excellent biocompatibility, optical stability, large Stokes shift, intense size-dependent emission and monodispersion, and thus could effectively...
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| Published in | Nanoscale Vol. 11; no. 39; pp. 17967 - 1798 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
10.10.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Au nanoclusters possess a series of excellent properties owing to their size being comparable to the Fermi wavelength of electrons. For example, they show excellent biocompatibility, optical stability, large Stokes shift, intense size-dependent emission and monodispersion, and thus could effectively compensate for the shortcomings of traditional organic fluorescent dyes and fluorescent quantum. In this review, we detail the latest developments of Au nanoclusters employed in the field of biomedicine, especially in oncology research, by summarizing the application of imaging, sensing and drug delivery based on their excellent luminescent properties and unique structural features. We also discuss the significant work relating to Au NCs that now is being devoted in other therapeutic strategies, such as radiotherapy, photothermal therapy and photodynamic therapy, for example. It is anticipated that this review will provide new insights and theoretical guidance to allow the advantages of Au nanoclusters to be realized in oncotherapy.
The structure, properties of gold nanoclusters and their applications in targeting anti-cancer fields have been reviewed. |
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| Bibliography: | Fenglong Wang gained his PhD in chemical engineering under the supervision of Professor Rose Amal and Dr Yijiao Jiang at the University of New South Wales, Australia. Afterwards, he worked as a specific researcher at Kyoto University within Professor Hiroshi Kitagawa's group from 2016 to 2018. He started his independent career as a professor of materials science at Shandong University in April 2018. His research interests are nanomaterials for solar energy conversion and environmental remediation applications. Chao Liu completed her PhD at Shandong University in 2015 and is now working as a postdoc fellow at Shanghai Jiaotong University. She worked in Ying Xu's laboratory in Georgia University in the US from 2013 to 2015. Her research interests are the mechanism of cancer development, biomarkers of early cancer, and new treatments for cancers. Hui Li received his PhD in 1999 from Shandong University. He then carried out his postdoctoral research in Nanjing University (1999) and University of Trento (2002). He has been promoted to full professor since 2005 in the School of Materials Science and Engineering at Shandong University. He has also been appointed as a Taishan Scholar by Shandong Province since 2013. His research interests are in the areas of wetting transformation of novel 2D materials, synthesis of low expansion alloy and refractory alloys and design of nano-electronic devices. Martina Stenzel studied chemistry at the University of Bayreuth, Germany, before completing her PhD in 1999 at the University of Stuttgart, Germany. She started as a postdoctoral fellow at UNSW in 2000 and is now a full professor. Her research interest is focused on the synthesis of functional polymers with complex architectures such as glycopolymers and other polymers for biomedical applications, especially polymers with in-built metal complexes for the delivery of metal-based anti-cancer drugs. She is a fellow of the Australian Academy of Science and currently the chair of the National Chemistry Committee. Jingjing Yang is currently pursuing a master's degree within the School of Materials Science and Engineering at Shandong University under the supervision of Professor Yanyan Jiang. She is conducting research on the synthesis of metal nanoparticles and clusters for targeting anti-cancer applications. Yanyan Jiang completed her PhD in Professor Martina Stenzel's group, School of Chemical Engineering at the University of New South Wales, Australia in 2016. She was awarded (2016) Japan Society for Promotion of Science (JSPS) Postdoctoral Research Fellowship at Kyoto University under the supervision of Professor Itaru Hamachi. Since 2018, she has been appointed as a full professor of materials science and engineering at Shandong University. Her research interests are in the synthesis of functional nanoparticles serving as anti-cancer drug carriers, biosensors, catalysts, and theoretical studies of the mechanism and properties of these nanoparticles. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 2040-3364 2040-3372 2040-3372 |
| DOI: | 10.1039/c9nr04301b |