Visible light-mediated chemistry of indoles and related heterocycles

The use of visible light and photoredox catalysis emerged as a powerful and sustainable tool for organic synthesis, showing the high value of distinctly different ways of bond creation. Indoles and related heterocycles are widely-present in natural products, biologically active compounds, drugs, and...

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Published inChemical Society reviews Vol. 48; no. 16; pp. 441 - 4423
Main Authors Festa, Alexey A, Voskressensky, Leonid G, Van der Eycken, Erik V
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 12.08.2019
Subjects
Agrochemicals
Heterocyclic compounds
Indoles
Natural products
Organic chemistry
Photoredox catalysis
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Summary:The use of visible light and photoredox catalysis emerged as a powerful and sustainable tool for organic synthesis, showing the high value of distinctly different ways of bond creation. Indoles and related heterocycles are widely-present in natural products, biologically active compounds, drugs, and agrochemicals. This review summarises the impact of visible light-promoted chemistry on the functionalization of indoles and on the synthesis and modification of indolines, indolin-2-ones, indolin-3-ones, and isatins. Almost 100 references starting from 2012 are cited. The impact of visible light-promoted chemistry on the functionalization of indoles and related heterocycles is reviewed.
Bibliography:Leonid G. Voskressensky received his PhD degree in Organic Chemistry from the Peoples' Friendship University of Russia in 1999. In 2001 he joined the Prof. Cosimo Altomare (Universita Degli Studi di Bari, Italy) group as a Post-Doc Fellow (Medicinal Chemistry). In 2001 he became an Assistant Professor, in 2006, an Associate Professor and in 2011, a Full Professor of the Organic Chemistry department of RUDN University. Since 2013, he has been the Dean of the Science Faculty of RUDN University. His group's scientific interests mainly focus on heterocyclic chemistry (with special emphasis on indole chemistry), methodology of domino reactions, new MCR reactions and medicinal chemistry.
Erik V. Van der Eycken is a Full Professor of Organic Chemistry and the Head of the Division of Molecular Design & Synthesis at KU Leuven, Belgium. He received his PhD degree (1987) in organic chemistry from the University of Ghent, Belgium. He spent time as a visiting scientist at the University of Graz (2002) with Prof. C. O. Kappe, at The Scripps Research Institute (La Jolla, USA) (2003) in the group of K. B. Sharpless, and at Uppsala University (2004) with Prof. M. Larhed and Prof. A. Hallberg. The main focus of his research is the development of new synthetic methodologies in combination with enabling techniques.
Alexey A. Festa was born in Moscow, Russia, in 1988. After graduating from the Chemistry Department of the Lomonosov Moscow State University in 2010, he defended his PhD thesis under the guidance of Professor L. G. Voskressensky at RUDN University in 2013. He has worked as an Assistant at the Organic Chemistry Department, RUDN University, since 2013 and as a Senior lecturer, since 2015. His area of scientific interest includes the chemistry of heterocyclic compounds, domino reactions in organic synthesis, and photochemistry.
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ISSN:0306-0012
1460-4744
DOI:10.1039/c8cs00790j