Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures

Immunoregulatory lipopolysaccharide (LPS) partial structures from Helicobacter pylori were synthesized and relates the structural uniqueness of H. pylori LPS with its immunobiological activity. The synthesis of immunoregulatory glycoconjugates, namely the active entity of lipopolysaccharide (LPS) fr...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 37; pp. 6577 - 6581
Main Authors Fujimoto, Yukari, Iwata, Masato, Imakita, Noriko, Shimoyama, Atsushi, Suda, Yasuo, Kusumoto, Shoichi, Fukase, Koichi
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.09.2007
Elsevier
Subjects
Chemistry
Chemistry, Organic
Helicobacter pylori
Physical Sciences
Science & Technology
ACTIVATION
ACID
ANALOGS
LIPID-A
DIVERGENT SYNTHESIS
BIOLOGICAL-ACTIVITIES
EXPRESSION
TLR4
LPS
Online AccessGet full text

Cover

More Information
Summary:Immunoregulatory lipopolysaccharide (LPS) partial structures from Helicobacter pylori were synthesized and relates the structural uniqueness of H. pylori LPS with its immunobiological activity. The synthesis of immunoregulatory glycoconjugates, namely the active entity of lipopolysaccharide (LPS) from Helicobacter pylori was achieved. The results of biological activities of the LPS partial structures provide the structural basis for the immunobiological activity, especially for the immune inhibitory activity of H. pylori LPS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.07.036