A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 18; pp. 235 - 238
Main Authors Zhang, Jing, Wang, Ningning, Li, Qian, Zhou, Yaxin, Luan, Yuxia
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 02.03.2021
Subjects
Breast cancer
Metastasis
Nanoparticles
Photodynamic therapy
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Summary:A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo , providing a very promising two-pronged strategy against BLBC metastasis. A two-pronged approach combining photodynamic therapy and blockade of epithelial-mesenchymal transition in a minimalist nanoplatform was proposed to combat metastasis of basal-like breast cancer.
Bibliography:Electronic supplementary information (ESI) available: Experimental section and Fig. S1. See DOI
10.1039/d0cc08162k
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc08162k