Mechanisms of Memory T Cell Activation and Effective Immunity

• Published in: Advances in experimental medicine and biology Vol. 850; p. 73
• Main Authors: Lauvau, Grégoire, Soudja, Saïdi M'Homa
• Format: Journal Article
• Language: English
• Published: United States 01.01.2015
• Subjects: Adaptive Immunity; Animals; Antigens, Bacterial - administration & dosage; Antigens, Ly - genetics; Antigens, Ly - immunology; Bacterial Infections - immunology; Bacterial Infections - microbiology; Bacterial Infections - pathology; Bacterial Infections - prevention & control; Biomarkers - metabolism; CD11c Antigen - genetics; CD11c Antigen - immunology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - microbiology; CD8-Positive T-Lymphocytes - pathology; Cytokines - genetics; Cytokines - immunology; Gene Expression; Humans; Immunization; Immunologic Memory; Lymphocyte Activation - drug effects; Mice; Monocytes - immunology; Monocytes - microbiology; Monocytes - pathology
• ISSN: 0065-2598
• DOI: 10.1007/978-3-319-15774-0_6

Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8(+)T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8(+) T cell activation and of cytolysis-independent mechanisms of host protection.