Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes

The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up...

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Bibliographic Details
Published inJournal of the Brazilian Chemical Society Vol. 27; no. 8; pp. 1512 - 1519
Main Authors Horta, Lívia, Mota, Yane, Barbosa, Gisele, Braga, Taniri, Marriel, Ivanildo, de Fátima, Ângelo, Modolo, Luzia
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 01.08.2016
Subjects
CHEMISTRY, MULTIDISCIPLINARY
phenolic aldehyde
urease inhibitor
natural product
urea
fertilizer additive
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Summary:The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.
ISSN:0103-5053
1678-4790
DOI:10.21577/0103-5053.20160208