Recent advances in transition metal-catalyzed C(sp)-H nitration
Nitroaromatic compounds play an important role in organic synthesis, medicinal chemistry and chemical industry. Among the recently reported synthetic methods to access nitroarenes, transition metal-catalyzed C(sp 2 )-H activation/nitration has become one of the most attractive protocols, showing hig...
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| Published in | Organic & biomolecular chemistry Vol. 17; no. 6; pp. 1351 - 1361 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
06.02.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Nitroaromatic compounds play an important role in organic synthesis, medicinal chemistry and chemical industry. Among the recently reported synthetic methods to access nitroarenes, transition metal-catalyzed C(sp
2
)-H activation/nitration has become one of the most attractive protocols, showing high regioselectivity, excellent functional group tolerance and step-economy. In this review, we discuss advances in direct C(sp
2
)-H nitration for the synthesis of nitroaromatic compounds and mechanistic insights over the past decade. We hope this will provide valuable information for researchers interested in the rapidly developing field of metal-catalyzed C(sp
2
)-H nitration.
This review updates advances of direct C(sp
2
)-H nitration for the synthesis of nitroaromatic compounds and the mechanisms during the past decade. |
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| Bibliography: | Zhoulong Fan was born in 1988, in Gansu, China. He obtained his B.Sc degree from China Pharmaceutical University in 2011. He received his Ph.D. degree in 2017 from Shanghai Institute of Materia Medica under the supervision of Prof. Ao Zhang. Now he works as a postdoctoral fellow in Jin-Quan Yu's lab at the Scripps Research Institute. His current research interest is focused on palladium catalyzed C-H bond activation. Hundred Talent Project Ao Zhang received his doctorate in Organic Chemistry from Shanghai Institute of Organic Chemistry in 2000, and did postdoctoral research in Medicinal Chemistry during 2001-2004 at Georgetown University Medical Center and Harvard Medical School McLean Hospital. In 2004, he was promoted to Research Investigator and Instructor of Harvard Medical School. In 2006, he received the Distinguished Young Investigator Award from Chinese Natural Science Foundation. He has coauthored more than 140 original articles and reviews. His research group focuses on the design and synthesis of novel small molecules as structural and functional probes for the diagnosis and treatment of brain disorders and cancers leading to the anticancer drug Simmiparib in Phase I clinical trial and Simitinib just filed IND application in China. Lirui Song was born in 1990, in Tianjin, China. She obtained her B.Sc. degree from Nankai University in 2013. Then she moved to Shanghai Institute of Materia Medica to continue her graduate study and obtained her Ph.D. degree in 2018. Her research interests include transition metal-free C-H bond activation and development of antiviral drugs. award from the Chinese Academy of Sciences, and became the Professor of Medicinal Chemistry at Shanghai Institute of Materia Medica (SIMM). In 2011, he was awarded the ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 1477-0520 1477-0539 1477-0539 |
| DOI: | 10.1039/c8ob02750a |