MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment

Myeloid-derived suppressor cells (MDSCs), one heterogeneous population of immature myeloid cells, have suppressive function on immune response during tumor, inflammation, infection and autoimmune diseases. The molecular mechanism underlying expansion and function of MDSCs is becoming appreciated to...

Full description

Saved in:
Bibliographic Details
Published inJournal of Cancer Vol. 10; no. 18; pp. 4350 - 4356
Main Authors Su, Yanping, Qiu, Ye, Qiu, Zhidong, Qu, Peng
Format Journal Article Book Review
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2019
Ivyspring International Publisher
Subjects
Apoptosis
Cancer therapies
Cytokines
Gene expression
Kinases
MicroRNAs
Phosphatase
Review
Transcription factors
Tumor
Myeloid-derived suppressor cells
MicroRNA
Online AccessGet full text

Cover

More Information
Summary:Myeloid-derived suppressor cells (MDSCs), one heterogeneous population of immature myeloid cells, have suppressive function on immune response during tumor, inflammation, infection and autoimmune diseases. The molecular mechanism underlying expansion and function of MDSCs is becoming appreciated to manipulate immune response in the diseases. MicroRNA (miRNAs) as one short noncoding RNAs, are involved in regulating cell proliferation, differentiation and maturation. However, it needs to be further studied how miRNAs mediate the development and function of MDSC in association with cancer and other diseases. In the review, we report and discuss recent studies that miRNAs networks regulate the differentiation, expansion and suppression function of MDSCs in tumor microenvironment or other diseases through different signaling pathways. Those studies may provide one novel potential approach for tumor immunotherapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Competing Interests: The authors have declared that no competing interest exists.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.35205