SOX6 expression and aneurysms of the thoracic and abdominal aorta

• Published in: iScience Vol. 27; no. 9; p. 110436
• Main Authors: Carmona-Berrio, David, Adarve-Rengifo, Isabel, Marshall, Andrea G., Vue, Zer, Hall, Duane D., Miller-Fleming, Tyne W., Actkins, Ky’Era V., Beasley, Heather K., Almonacid, Paula M., Barturen-Larrea, Pierina, Wells, Quinn S., Lopez, Marcos G., Garza-Lopez, Edgar, Dai, Dao-Fu, Shao, Jianqiang, Neikirk, Kit, Billings, Frederic T., Curci, John A., Cox, Nancy J., Gama, Vivian, Hinton, Antentor, Gomez, Jose A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.09.2024; Elsevier
• Subjects: Cardiovascular medicine; Medical science; Molecular Genetics; Cardiovascular medicine; Medical science; Molecular Genetics
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2024.110436

Abdominal and thoracic aortic aneurysms (AAAs, TAAs) remain a major cause of deaths worldwide, in part due to the lack of reliable prognostic markers or early warning signs. Sox6 has been found to regulate renin controlling blood pressure. We hypothesized that Sox6 may serve as an important regulator of the mechanisms contributing to hypertension-induced aortic aneurysms. Phenotype and laboratory-wide association scans in a clinical cohort found that SOX6 gene expression is associated with aortic aneurysm in subjects of European ancestry. Sox6 and tumor necrosis factor alpha (TNF-α) expression were upregulated in aortic tissues from patients affected by either AAA or TAA. In Sox6 knockout mice with angiotensin-II-induced AAA, we found that Sox6 plays critical role in the development and progression of AAA. Our data support a regulatory role of SOX6 in the development of hypertension-induced AAA, suggesting that Sox6 may be a therapeutic target for the treatment of aortic aneurysms. [Display omitted] •Transcription factor SOX6 is associated with abdominal and thoracic aortic aneurysm•LabWAS provides clinical measurements associated with aortic aneurysm diagnosis•Knocking out Sox6 attenuated hypertension-induced abdominal aortic aneurysm Medical science; Cardiovascular medicine; Molecular Genetics