Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications

Inorganic nanomaterials have been studied extensively in recent years because of their unique physical and chemical characteristics. Moreover, ultra-small nanoclusters (USNCs), which are less than 3 nm in size, exhibit extraordinary properties different from those of larger-sized nanoparticles. For...

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Published inBiomaterials science Vol. 7; no. 2; pp. 48 - 489
Main Authors Wang, Qiyue, Wang, Shuying, Hu, Xi, Li, Fangyuan, Ling, Daishun
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 29.01.2019
Subjects
Animals
Assembly
Biomedical materials
Chemistry Techniques, Synthetic
Fluorescence
Humans
Iron oxides
Nanoclusters
Nanomaterials
Nanomedicine - methods
Nanoparticles
Nanostructures - chemistry
Noble metals
Organic chemistry
Synthesis
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Summary:Inorganic nanomaterials have been studied extensively in recent years because of their unique physical and chemical characteristics. Moreover, ultra-small nanoclusters (USNCs), which are less than 3 nm in size, exhibit extraordinary properties different from those of larger-sized nanoparticles. For example, ultra-small iron oxide nanoclusters (NCs) show paramagnetic properties; ultra-small noble metal NCs exhibit bright fluorescence; most USNCs gain in vivo renal clearance capability to guarantee safety. Therefore, USNCs could be promising safe materials for biomedical applications. In this mini-review, we summarize recent advances in the controlled synthesis, assembly, and biomedical applications of USNCs. We also discussed future challenges and perspectives in the development of USNC-based nanomedicine. This Minireview summarizes recent advances in the controlled synthesis, assembly, and biomedical applications of ultra-small nanoclusters.
Bibliography:Qiyue Wang received her B.S. (2017) in the School of Materials Science and Engineering from Zhengzhou University. She is now a doctoral candidate in the College of Pharmaceutical Sciences at Zhejiang University under the guidance of Prof. Daishun Ling. She currently focuses on nanoparticle functionalization and assembly for theranostic applications.
Daishun Ling received his Ph.D. (2013) from School of Chemical and Biological Engineering at Seoul National University. Later, he worked as a senior researcher at the Center for Nanoparticle Research, Institute for Basic Science. He joined the faculty of the College of Pharmaceutical Sciences at Zhejiang University in 2014 through "Zhejiang University 100 Talent Professor" and "National 1000 Young Talent Program". He currently focuses on the synthesis and assembly of functional nanoparticles for biomedical applications.
Shuying Wang received her B.S. (2018) in the West China School of Pharmacy from Sichuan University. She is now a doctoral candidate in the College of Pharmaceutical Sciences at Zhejiang University under the guidance of Prof. Daishun Ling. She currently focuses on functional assembly of nanoparticles for diagnostic and therapeutic applications.
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ISSN:2047-4830
2047-4849
DOI:10.1039/c8bm01200h