Constituent Analysis and Quality Evaluation of Epimedii Folium from Different Species

Epimedii Folium (EF) is a commonly used traditional Chinese drug that includes many species. In Chinese Pharmacopoeia (2020 edition), EF includes Epimedium brevicornu Maxim, E. Sagittatum (Sieb. et Zucc) Maxim, E. pubescens Maxim, E. koreanum Nakai, and Epimedium Wushanense T.S. Ying. It has been re...

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Published inJournal of chemistry Vol. 2023; pp. 1 - 18
Main Authors Xue, Jia, Chen, Haijie, Zhou, Yongyi, Yuan, Jiahuan, Cai, Zhichen, Wu, Nan, Chen, Cuihua, Zou, Lisi, Yin, Shengxin, Yang, Wei, Liu, Xunhong, Cheng, Jianming, Sun, Yihao
Format Journal Article
LanguageEnglish
Published New York Hindawi 2023
Hindawi Limited
Wiley
Subjects
Amino acids
Biotechnology
Chinese medicine
Chromatography
Constituents
Correlation analysis
Discriminant analysis
Ethanol
Flavonoids
Ions
Liquid chromatography
Mass spectrometry
Phenolic acids
Quadrupoles
Quality assessment
Quality control
Quality standards
Scientific imaging
Variance analysis
China
North Korea
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Summary:Epimedii Folium (EF) is a commonly used traditional Chinese drug that includes many species. In Chinese Pharmacopoeia (2020 edition), EF includes Epimedium brevicornu Maxim, E. Sagittatum (Sieb. et Zucc) Maxim, E. pubescens Maxim, E. koreanum Nakai, and Epimedium Wushanense T.S. Ying. It has been reported that the active constituents in EF are different, resulting in the uneven quality of commercial medicinal materials. To explore the specific differences and make a comprehensive quality evaluation of EF, we established an analytical method to simultaneously detect 45 constituents including 23 flavonoids, 4 phenolic acids, 12 amino acids, 5 nucleosides, and 1 alkaloid in 5 species of EF, based on ultrafast performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry (UFLC-QTRAP-MS/MS). In addition, orthogonal partial least squares discriminant analysis (OPLS-DA), analysis of variance (ANOVA), and grey correlation analysis (GRA) were used to discriminate and evaluate different species of samples. The results showed that EF could be divided into three categories and EBM was superior to the other four species. This study provides data basis for the comprehensive evaluation and a new perspective on the quality control of EF from different species.
ISSN:2090-9063
2090-9071
DOI:10.1155/2023/4221158