The first in vivo application of synthetic polymers based on methacrylic acid as an aflatoxin sorbent in an animal model

• Published in: Mycotoxin research Vol. 35; no. 3; pp. 293 - 307
• Main Authors: Arak, Homa, Karimi Torshizi, Mohammad Amir, Hedayati, Mehdi, Rahimi, Shaban
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2019; Springer Nature B.V
• Subjects: Adsorption; Aflatoxin B1; Aflatoxins; Animal models; Biocompatibility; Biomedical and Life Sciences; Chemical synthesis; Chemisorption; Chemistry/Food Science; Conversion ratio; Data processing; Enlargement; Feed conversion; Injury prevention; Life Sciences; Medical Microbiology; Medicine/Public Health; Methacrylic acid; Microbiology; Minerals; Organic chemistry; Organs; Original Article; Sorbents; Duckling; Moleculary imprinted polymer; Isothermal analysis; Aflatoxin
• ISSN: 0178-7888; 1867-1632
• DOI: 10.1007/s12550-019-00353-z

This study attempts to evaluate the potential aflatoxin binder activity of a molecularly imprinted polymer (TMU95) synthesized to target the aflatoxin B 1 (AFB 1 ) analog molecule in comparison to a commercial toxin binder (CTB). Adsorption experiments were carried out to assess the ability to bind to AFB 1 at various pH values. The strength of binding was investigated by the chemisorption index. The isothermal analysis was used to determine the maximum adsorption capacity values. The ability of TMU95 and CTB to adsorb essential minerals was evaluated and the obtained data suggested that CTB would significantly reduce availability of them compared to TMU95. The in vivo efficacy of TMU95 as an aflatoxin (AF) binder in duckling exposed to aflatoxin-contaminated feed from 4 to 18 days of age in comparison to the CTB was also assessed. TMU95 and CTB were effective in reducing the adverse effects caused by AFs on feed conversion ratio of duckling ( p  ≤ 0.01), and also showed a minor reduction of injuries caused by AFs on visceral organs enlargement ( p  ≤ 0.01). It was concluded that TMU95 could absorb AFB 1 in vitro efficiently and had beneficial health effects that could alleviate some of the toxic effects of AFs on growing duckling performance similar to CTB.