Propane phosphonic acid anhydride: a new promoter for the one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2(1 H)-ones

Propane phosphonic acid anhydride has been found to promote the Biginelli synthesis of 3,4-dihydropyrimidin-2(1 H)-ones. The use of this agent is characterized by moderate costs, low toxicity and simple workup conditions.

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Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 8; pp. 1421 - 1423
Main Authors Zumpe, Franz L., Flüß, Melanie, Schmitz, Krischan, Lender, Andreas
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.02.2007
Elsevier
Subjects
3,4-Dihydropyrimidin-2(1 H)-ones
Biginelli reaction
Chemistry
Chemistry, Organic
Heterocycles
Multicomponent reaction
Physical Sciences
Propane phosphonic acid anhydride
Science & Technology
Heterocycles
3,4-Dihydropyrimidin-2(1 H)-ones
Biginelli reaction
Propane phosphonic acid anhydride
Multicomponent reaction
3,4-dihydropyrimidin-2(IH)-ones
DIHYDROPYRIMIDINONES
propane phosphonic acid anhydride
heterocycles
EFFICIENT SYNTHESIS
PROTOCOL
multicomponent reaction
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Summary:Propane phosphonic acid anhydride has been found to promote the Biginelli synthesis of 3,4-dihydropyrimidin-2(1 H)-ones. The use of this agent is characterized by moderate costs, low toxicity and simple workup conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.12.098