Antiulcerogenic effects of Campomanesia xanthocarpa

• Published in: Journal of ethnopharmacology Vol. 94; no. 1; pp. 55 - 57
• Main Authors: Markman, Blanca Elena Ortega, Bacchi, Elfriede Marianne, Kato, Edna Tomiko Myiake
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.09.2004; Elsevier
• Subjects: Animals; anti-ulcer activity; Anti-Ulcer Agents - chemistry; Anti-Ulcer Agents - therapeutic use; Anti-Ulcer Agents - toxicity; Antiulcerogenic activity; Biological and medical sciences; Brazil; Campomanesia; Campomanesia xanthocarpa; Chromatography, Thin Layer; Female; gabiroba; General pharmacology; leaves; Male; Medical sciences; medicinal plants; Mice; Myrtaceae; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; plant extracts; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plant Extracts - toxicity; Plant Leaves; Plants, Medicinal; Rats; Rats, Wistar; Stomach Ulcer - prevention & control; Toxicity Tests, Acute; traditional medicine; Brazil; Myrtaceae; Campomanesia xanthocarpa; Antiulcerogenic activity; Pharmacognosy; Dicotyledones; Angiospermae; Spermatophyta; Antiulcer agent; Medicinal plant
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2004.04.025

Campomanesia xanthocarpa O. Berg., popularly known as “gabiroba”, is used in Brazilian folk medicine for ulcer treatment. The hydroalcoholic extract of Campomanesia xanthocarpa leaves was evaluated for antiulcerogenic activity, acute toxicity and phytochemical profile. Oral administration of the extract at 400 mg/kg proved to be effective in preventing gastric ulceration in rats and did not produce toxic symptoms in mice in doses up to 5 g/kg. TLC screening methods revealed the presence of flavonoids, saponins and tannins.