The influence of carrying MEFV gene variants on juvenile systemic lupus erythematosus
Juvenile-onset systemic lupus erythematosus (jSLE) patients typically have a more severe disease course than adults with SLE. We aimed to assess the prevalence and disease course of jSLE patients carrying MEFV variants. MEFV variant analyses were performed in 44 jSLE patients and effect of these var...
Saved in:
Published in | Rheumatology international Vol. 41; no. 1; pp. 157 - 161 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.01.2021
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Juvenile-onset systemic lupus erythematosus (jSLE) patients typically have a more severe disease course than adults with SLE. We aimed to assess the prevalence and disease course of jSLE patients carrying
MEFV
variants.
MEFV
variant analyses were performed in 44 jSLE patients and effect of these variants on disease severity and course was analyzed by SLEDAI score and SLICC/ACR index. Ten of the patients (22.7%) had a
MEFV
variant. The median (min–max) SLEDAI score and SLICC/ACR index were 2(0–13) and 0(0–3), respectively. Median age at disease onset, disease duration, SLICC/ACR indexes, SLEDAI scores, clinical and laboratory findings of the patients were comparable in carriers of variants and non-carriers. Nineteen patients (43.2%) had biopsy-proven lupus nephritis and four of these patients had
MEFV
variants. There was no significant difference between patients with and without
MEFV
carriers in terms of lupus nephritis. Even though not significant statistically, renal involvement was milder in
MEFV
carriers than non-carriers. The presence of
MEFV
variants does not increase the overall susceptibility to jSLE in our cohort, while larger number of patients is required to display the protective role of
MEFV
variants in jSLE. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0172-8172 1437-160X |
DOI: | 10.1007/s00296-019-04420-7 |