Association between ATM polymorphisms and cancer risk: a meta-analysis

• Published in: Molecular biology reports Vol. 39; no. 5; pp. 5719 - 5725
• Main Authors: Shen, Li, Yin, Zhi-Hua, Wan, Yan, Zhang, Yue, Li, Kun, Zhou, Bao-Sen
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2012; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Ataxia Telangiectasia Mutated Proteins; Biomedical and Life Sciences; Breast cancer; Cancer; Cell Cycle Proteins - genetics; DNA-Binding Proteins - genetics; Gene Frequency - genetics; Genetic Association Studies; Genetic Heterogeneity; Genetic Predisposition to Disease; Genotype & phenotype; Genotypes; Glioma; Histology; Humans; Life Sciences; Lung cancer; Meta-analysis; Molecular biology; Morphology; Neoplasms - genetics; Odds Ratio; Pancreatic cancer; Polymorphism; Polymorphism, Single Nucleotide - genetics; Protein-Serine-Threonine Kinases - genetics; Publication Bias; Risk Factors; Tumor Suppressor Proteins - genetics; Carcinomas; Cancer susceptibility; Ataxia-telangiectasia mutated; ATM; Gene polymorphism; Cancer risk; Meta-analysis
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-011-1381-2

To date, epidemiological studies have assessed the association between Ataxia-telangiectasia mutated (ATM) gene polymorphisms and cancer risk, including lung cancer, breast cancer, glioma and pancreatic cancer. However, the results of these studies remain controversial. We aimed to examine the associations between two SNPs (rs664143 and rs664677) and cancer risk by conducting a meta-analysis of case–control studies. A total of 12 publications were included in this meta-analysis, 8 for rs664143 and 7 for rs664677. Overall, rs664143 heterozygote carriers turned out to be associated with cancer risk (OR = 1.18, 95% CI 1.02–1.36). In the subgroup analysis by cancer type, we observed that the ATM rs664143 polymorphism was significantly associated with lung cancer risk (GA vs. GG: OR = 1.48, 95% CI 1.18–1.85, AA vs. GG: OR = 1.51, 95% CI 1.18–1.93) and rs664677 polymorphism was associated with decreased lung cancr risk and increased breast cancer risk (for lung cancer: TC vs. TT: OR = 0.76, 95% CI 0.62–0.92, CC vs. TT: OR = 0.80, 95% CI 0.64–0.99 and for breast cancer: TC vs. TT: OR = 1.42, 95% CI 1.17–1.73, CC vs. TT: OR = 1.51, 95% CI 1.21–1.87). In the subgroup analysis by region, we also observed that individuals with ATM rs664143 GA or AA genotype had an obvious increased cancer risk among Asian people (GA vs. GG: OR = 1.40, 95% CI 1.20–1.63, AA vs. GG: OR = 1.37, 95% CI 1.16–1.62). In conclusion, ATM rs664143 polymorphism was associated with cancer susceptibility. ATM rs664143 polymorphism was significantly associated with lung cancer risk. ATM rs664677 polymorphism was associated with decreased lung cancer risk as well as increased breast cancer risk.