Diagnostic Accuracy of MRI for Detecting Cervical Invasion in Patients with Endometrial Carcinoma: A Meta-Analysis

• Published in: Journal of Cancer Vol. 12; no. 3; pp. 754 - 764
• Main Authors: Bi, Qiu, Bi, Guoli, Wang, Junna, Zhang, Jie, Li, Hongliang, Gong, Xiarong, Ren, Lixiang, Wu, Kunhua
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2021; Ivyspring International Publisher
• Subjects: Accuracy; Cancer; Cervix; Endometrial cancer; Human subjects; Hysterectomy; Magnetic fields; Magnetic resonance imaging; Meta-analysis; Oophorectomy; Pathology; Patients; Research Paper; Denmark; Italy; Turkey; United Kingdom > UK; Portugal; Japan; meta-analysis; magnetic resonance imaging; endometrial carcinoma; cervical invasion; diffusion weighted imaging
• ISSN: 1837-9664; 1837-9664
• DOI: 10.7150/jca.52797

To evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) in the preoperative assessment of cervical invasion and to analyse the influence of different imaging protocols in patients with endometrial carcinoma. An extensive search of articles about MRI for assessing cervical invasion in patients with endometrial carcinoma was performed on PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials from January 2000 to July 2020. Two reviewers independently evaluated the methodological quality of each study by using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Diagnostic accuracy results and additional useful information were extracted. The pooled estimation data was obtained by statistical analysis. A total of 42 eligible studies were included in the meta-analysis. Significant evidence of heterogeneity was found for detecting cervical invasion ( = 74.1%, = 0.00 for sensitivity and = 56.2%, = 0.00 for specificity). The pooled sensitivity and specificity of MRI were 0.58 and 0.95 respectively. The use of higher field strength (3.0 T) demonstrated higher pooled sensitivity (0.74). Using diffusion weighted imaging (DWI) alone presented higher pooled sensitivity (0.86) than using other sequences. The studies that used dynamic contrast-enhanced MRI (DCE-MRI) alone showed higher sensitivity (0.80) and specificity (0.96) than those that used T2-weighted imaging (T2WI) alone. MRI shows high specificity for detecting cervical infiltration in endometrial carcinoma. Using DWI or a 3.0-T device may improve the pooled sensitivity. DCE-MRI demonstrates higher pooled sensitivity and specificity than T2WI.