Stopping Bleeding in Hereditary Telangiectasia

Hereditary hemorrhagic telangiectasia, also known as Rendu-Osler-Weber syndrome, is a familial disease in which telangiectases occur in the skin, mucosal surfaces, and solid organs 1 , 2 . Small telangiectases are a mild cosmetic problem, but larger lesions can be a source of chronic blood loss, sys...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 330; no. 25; pp. 1822 - 1823
Main Author Phillips, Martin D
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.06.1994
Subjects
Acids
Adult
Aminocaproates - therapeutic use
Chromosomes
Epistaxis - prevention & control
Fistula
Genes
Hemorrhage
Hemorrhage - prevention & control
Humans
Iron
Recurrence
Telangiectasia, Hereditary Hemorrhagic - complications
Telangiectasia, Hereditary Hemorrhagic - genetics
Telangiectasia, Hereditary Hemorrhagic - therapy
Thrombosis
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Summary:Hereditary hemorrhagic telangiectasia, also known as Rendu-Osler-Weber syndrome, is a familial disease in which telangiectases occur in the skin, mucosal surfaces, and solid organs 1 , 2 . Small telangiectases are a mild cosmetic problem, but larger lesions can be a source of chronic blood loss, systemic emboli, hypoxemia, hepatic dysfunction, and high-output cardiac failure. The treatment of troublesome telangiectasia in patients with this disease has always been difficult, because bleeding sites may be many and scattered. Treatment often requires multiple blood transfusions, large doses of iron, and various invasive procedures in order to make the diagnosis, staunch bleeding, or prevent recurrent . . .
Bibliography:SourceType-Other Sources-1
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ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199406233302511