Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarize...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 47; pp. 6629 - 6671
Main Authors Zhu, Jun-Long, Xu, Zheng, Yang, Yangyang, Xu, Lin
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 2019
Subjects
Copper
Fluorescent indicators
Hydrogen peroxide
Hydrogen sulfide
Imaging
Lipids
Lysosomes
Medical science
Organic chemistry
Thiols
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Summary:In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarizes the recent advances in the design and preparation of small-molecule fluorescent probes for specific detection of chemical species inside lysosomes. In addition, their properties and applications for the detection and imaging of pH, H 2 O 2 , HOCl, O 2 &z.rad; − , lipid peroxidation, H 2 S, HSO 3 − , thiols, NO, ONOO − , HNO, Zn 2+ , Cu 2+ , enzymes, etc. in lysosomes are discussed as well. This feature article comprehensively summarizes the development of small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes.
Bibliography:Lin Xu received his PhD degree in Chemistry from the East China University of Science and Technology (ECUST, Shanghai) in 2012 under the supervision of Professor Xuhong Qian. Subsequently, he joined the East China Normal University (ECNU, Shanghai) as an assistant professor and was promoted to an associate professor and a professor in 2014 and 2018, respectively. He carried out two-year postdoctoral research at the University of Cambridge with Prof. Jonathan Nitschke during 2015-2017. His research interests focus mainly on supramolecular fluorescent chemistry.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc03299a