Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging for Monitoring the Early Response to ZD6474 from Nasopharyngeal Carcinoma in Nude Mouse

• Published in: Scientific reports Vol. 5; no. 1; p. 16389
• Main Authors: Cui, Yanfen, Zhang, Caiyuan, Li, Xiaoming, Liu, Huanhuan, Yin, Bing, Xu, Tianyong, Zhang, Yong, Wang, Dengbin
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 17.11.2015
• Subjects: Angiogenesis; Animals; Antineoplastic Agents - therapeutic use; Carcinoma; Cell Line, Tumor; Diffusion coefficient; Diffusion Magnetic Resonance Imaging; Growth factors; Humans; Image Processing, Computer-Assisted; Investigations; Ki-67 Antigen - metabolism; Magnetic resonance imaging; Mice; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - diagnostic imaging; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - pathology; Perfusion; Piperidines - therapeutic use; Quinazolines - therapeutic use; Radiography; Reproducibility; Throat cancer; Transplantation, Heterologous; Tumors

Early therapeutic effects of anti-angiogenic agent ZD6474 upon nasopharyngeal carcinoma (NPC) in nude mouse were monitored by using intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). Mice bearing NPC underwent IVIM DWI at baseline and after 1, 3, and 7 days of treatment with ZD647...