Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging for Monitoring the Early Response to ZD6474 from Nasopharyngeal Carcinoma in Nude Mouse

• Published in: Scientific reports Vol. 5; no. 1; p. 16389
• Main Authors: Cui, Yanfen, Zhang, Caiyuan, Li, Xiaoming, Liu, Huanhuan, Yin, Bing, Xu, Tianyong, Zhang, Yong, Wang, Dengbin
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 17.11.2015
• Subjects: Angiogenesis; Animals; Antineoplastic Agents - therapeutic use; Carcinoma; Cell Line, Tumor; Diffusion coefficient; Diffusion Magnetic Resonance Imaging; Growth factors; Humans; Image Processing, Computer-Assisted; Investigations; Ki-67 Antigen - metabolism; Magnetic resonance imaging; Mice; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - diagnostic imaging; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - pathology; Perfusion; Piperidines - therapeutic use; Quinazolines - therapeutic use; Radiography; Reproducibility; Throat cancer; Transplantation, Heterologous; Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep16389

Early therapeutic effects of anti-angiogenic agent ZD6474 upon nasopharyngeal carcinoma (NPC) in nude mouse were monitored by using intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). Mice bearing NPC underwent IVIM DWI at baseline and after 1, 3, and 7 days of treatment with ZD6474 or vehicle (n = 12 per group). Parameters of apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion fraction (f), and blood pseudodiffusion coefficient (D*) at different time points were compared between the two groups or within the treated group. In the treated group, the perfusion-related parameters f and D* of the tumors decreased significantly on day 1 while the diffusion-related parameters ADC and D were significantly higher beginning on day 3 compared with the control group. The decreases in f on day 1 and D* on day 3 were moderately correlated with the smaller tumor size change on day 7. Moderate correlations were established between MVD and f and D* as well as between increased TUNEL or decreased Ki-67 index and ADC and D. This study supports that IVIM DWI is sensitive to detect the ZD6474-induced changes in NPC in nude mouse and the f parameter could predict early response to anti-angiogenic treatment.