Catalytic asymmetric dearomatization (CADA) reaction-enabled total synthesis of indole-based natural products

Covering: 2000 up to 2019. Catalytic asymmetric dearomatization (CADA) reactions have witnessed considerable development in recent years. As the most extensively studied sub-branch, asymmetric dearomatization reactions of indole derivatives have attracted particular interest from the synthetic organ...

Full description

Saved in:
Bibliographic Details
Published inNatural product reports Vol. 36; no. 11; pp. 1589 - 165
Main Authors Zheng, Chao, You, Shu-Li
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 13.11.2019
Subjects
Asymmetry
Chemical synthesis
Indoles
Natural products
Online AccessGet full text

Cover

More Information
Summary:Covering: 2000 up to 2019. Catalytic asymmetric dearomatization (CADA) reactions have witnessed considerable development in recent years. As the most extensively studied sub-branch, asymmetric dearomatization reactions of indole derivatives have attracted particular interest from the synthetic organic community since the molecular complexity can be rapidly enhanced with this method and the asymmetric total synthesis of a series of alkaloid natural products may be achieved with this strategy. In this review, we present the recent contributions in this dynamic area. The synthetic details are documented according to their different dearomative cyclization strategies. The recent enantioselective total syntheses of natural products enabled by catalytic asymmetric dearomatization reactions of indole derivatives are presented.
Bibliography:Chao Zheng was born in Hubei Province, China in 1985. He studied Chemistry and received his BSc Degree at Shanghai Jiao Tong University in 2007. He obtained his PhD Degree at Shanghai Institute of Organic Chemistry (SIOC) under the supervision of Prof. Shu-Li You and Prof. Yu-Xue Li in 2012. Then he joined Prof. Shu-Li You's group at SIOC and was promoted to Associate Professor in 2015. His current work is focused on the mechanistic understanding of homogeneous organic reactions by employing computational chemistry, and developing new catalytic asymmetric reactions. He has published over 30 journal papers and 4 book chapters.
Shu-Li You received his BSc in Chemistry from Nankai University in 1996. He then obtained his PhD from Shanghai Institute of Organic Chemistry (SIOC) in 2001 under the supervision of Prof. Lixin Dai before doing postdoctoral studies with Prof. Jeffery Kelly at The Scripps Research Institute. From 2004, he worked at the Genomics Institute of the Novartis Research Foundation as a PI before returning to SIOC as a Professor in 2006. He is currently the director of the State Key Laboratory of Organometallic Chemistry of SIOC. His research interests mainly focus on asymmetric C-H functionalization and catalytic asymmetric dearomatization (CADA) reactions. He has published over 250 research papers and edited two books.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0265-0568
1460-4752
DOI:10.1039/c8np00098k