Mental Disorders Linked to Crosstalk between The Gut Microbiome and The Brain
Often called the second brain, the gut communicates extensively with the brain and . The conversation between these two organs affects a variety of physiological mechanisms that are associated with our mental health. Over the past decade, a growing body of evidence has suggested that the gut microbi...
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Published in | Experimental neurobiology Vol. 29; no. 6; pp. 403 - 416 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
The Korean Society for Brain and Neural Sciences
31.12.2020
한국뇌신경과학회 |
Subjects | |
Online Access | Get full text |
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Summary: | Often called the second brain, the gut communicates extensively with the brain and
. The conversation between these two organs affects a variety of physiological mechanisms that are associated with our mental health. Over the past decade, a growing body of evidence has suggested that the gut microbiome builds a unique ecosystem inside the gastrointestinal tract to maintain the homeostasis and that compositional changes in the gut microbiome are highly correlated with several mental disorders. There are ongoing efforts to treat or prevent mental disorders by regulating the gut microbiome using probiotics. These attempts are based on the seminal findings that probiotics can control the gut microbiome and affect mental conditions. However, some issues have yet to be conclusively addressed, especially the causality between the gut microbiome and mental disorders. In this review, we focus on the mechanisms by which the gut microbiome affects mental health and diseases. Furthermore, we discuss the potential use of probiotics as therapeutic agents for psychiatric disorders. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1226-2560 2093-8144 |
DOI: | 10.5607/en20047 |