mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila

Establishment of the anteroposterior and dorsoventral axes in the Drosophila egg chamber requires reciprocal signaling between the germ line and soma. Upon activation of the Drosophila EGF receptor in the posterior follicle cells, these cells signal back to the oocyte, resulting in a reorganization...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 124; no. 16; pp. 3197 - 3207
Main Authors Newmark, P A, Mohr, S E, Gong, L, Boswell, R E
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Limited 01.08.1997
Subjects
Amino Acid Sequence
Animals
Body Patterning - physiology
Caenorhabditis elegans - genetics
Cell Nucleus - chemistry
Drosophila
Drosophila - embryology
Drosophila - genetics
Drosophila Proteins
Female
Genes, Insect - genetics
Homeodomain Proteins - genetics
Insect Proteins - analysis
Insect Proteins - genetics
Kinesins - analysis
Mice - genetics
Microtubules
Molecular Sequence Data
Nuclear Proteins - analysis
Nuclear Proteins - genetics
Nuclear Proteins - physiology
Oocytes - chemistry
Oocytes - growth & development
Oogenesis - genetics
Phenotype
Recombinant Fusion Proteins
RNA, Messenger - analysis
RNA-Binding Proteins
Sequence Homology, Amino Acid
Trans-Activators - genetics
Transforming Growth Factor alpha
Transforming Growth Factors - analysis
Transforming Growth Factors - genetics
Xenopus laevis - genetics
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Summary:Establishment of the anteroposterior and dorsoventral axes in the Drosophila egg chamber requires reciprocal signaling between the germ line and soma. Upon activation of the Drosophila EGF receptor in the posterior follicle cells, these cells signal back to the oocyte, resulting in a reorganization of the oocyte cytoplasm and anterodorsal migration of the oocyte nucleus. We demonstrate that the gene mago nashi (mago) encodes an evolutionarily conserved protein that must be localized within the posterior pole plasm for germ-plasm assembly and Caenorhabditis elegans mago is a functional homologue of Drosophila mago. In the absence of mago+ function during oogenesis, the anteroposterior and dorsoventral coordinates of the oocyte are not specified and the germ plasm fails to assemble.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.124.16.3197