Primary pulmonary Ewing's sarcoma/primitive neuroectodermal tumor in a 67-year-old man

• Published in: Journal of Korean medical science Vol. 22 Suppl; no. Suppl; pp. S159 - S163
• Main Authors: Lee, Yoon Young, Kim, Do Hoon, Lee, Ji Hye, Choi, Jong Sang, In, Kwang Ho, Oh, Yu Whan, Cho, Kyung Hwan, Roh, Yong Kyun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.09.2007
• Subjects: Aged; Calmodulin-Binding Proteins - genetics; Case Report; Chromosome Breakage; Chromosomes, Human, Pair 22 - genetics; Diagnosis, Differential; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Neuroectodermal Tumors, Primitive, Peripheral - diagnosis; Neuroectodermal Tumors, Primitive, Peripheral - genetics; Neuroectodermal Tumors, Primitive, Peripheral - metabolism; Neuroectodermal Tumors, Primitive, Peripheral - pathology; RNA-Binding Protein EWS; RNA-Binding Proteins - genetics; Sarcoma, Ewing - diagnosis; Sarcoma, Ewing - genetics; Sarcoma, Ewing - metabolism; Sarcoma, Ewing - pathology
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2007.22.s.s159

Extraskeletal Ewing's sarcoma (EES) is a branch of neuroectodermal tumor (PNET), which is very rare soft tissue sarcoma. We report a case of EES/PNET arising is the lung of a 67-yr-old man. Computed tomography, bone scintigraphy, and positron emission tomography confirmed the mass to have a primary pulmonary origin. The mass showed positive reactivity in the Periodic Acid Schiff (PAS) stain and MIC-2 immunoreactivity in immunohistochemical stain. Fluorescence in situ hybridization (FISH) was performed, which revealed an EWSR1 (Ewing sarcoma breakpoint region 1) 22q12 rearrangement. The diagnosis was confirmed both pathologically and genetically. The mass lesion was resected, and the patient is currently undergoing chemotherapy.