Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population

• Published in: Journal of genetics Vol. 90; no. 1; pp. 151 - 155
• Main Authors: KIM, HAK-JAE, CHUNG, JOO-HO, KANG, SUNGWOOK, KIM, SU-KANG, CHO, BYOUNG-SOO, KIM, SUNG-DO, HAHN, WON-HO
• Format: Journal Article
• Language: English
• Published: India Springer-Verlag 01.04.2011; Springer Nature B.V
• Subjects: Adolescent; Adult; Animal Genetics and Genomics; Antigens, CD - genetics; Antigens, Differentiation, T-Lymphocyte - genetics; Biomedical and Life Sciences; CD28 Antigens - genetics; Child; CTLA-4 Antigen; Evolutionary Biology; Female; Genetics; Glomerulonephritis, IGA - genetics; Glomerulonephritis, IGA - pathology; Humans; Indexing in process; Inducible T-Cell Co-Stimulator Protein; Kidney diseases; Life Sciences; Logistic Models; Male; Mesangial Cells - pathology; Microbial Genetics and Genomics; Middle Aged; Pediatrics; Plant Genetics and Genomics; Podocytes - pathology; Polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Proteinuria - genetics; Proteinuria - pathology; Republic of Korea; Research Note; South Korea; CD28; IgA nephropathy; inducible co-stimulator (ICOS); single nucleotide polymorphism; cytotoxic T-lymphocyte antigen 4 (CTLA4)
• ISSN: 0022-1333; 0973-7731
• DOI: 10.1007/s12041-011-0042-5

Primary IgA nephropathy (IgAN) is the most common glomerular disease in children and adolescents who undergo renal biopsy because of isolated microscopic haematuria or haematuria associated with proteinuria. Kim et al tested single nucleotide polymorphisms (SNPs) of CTLA4/CD28/ICOS genes, and they were found to be associated with pathophisipology of paediatric IgAN in Korean population.