Effect of metabolic syndrome and its components on the risk and prognosis of cervical cancer: A literature review

• Published in: Gynecologic oncology reports Vol. 54; p. 101438
• Main Authors: Kajabwangu, Rogers, Izudi, Jonathan, Bazira, Joel, Ssedyabane, Frank, Turanzomwe, Stuart, Birungi, Abraham, Ngonzi, Joseph, Bajunirwe, Francis, Randall, Thomas C
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2024; Elsevier
• Subjects: Cervical cancer; Human papillomavirus; Metabolic syndrome; Special Section on Global Gynecologic Oncology; Metabolic syndrome; Human papillomavirus; Cervical cancer
• ISSN: 2352-5789; 2352-5789
• DOI: 10.1016/j.gore.2024.101438

•Metabolic syndrome and cervical cancer are both highly prevalent globally.•Metabolic syndrome and its components increase the risk of cervical cancer.•Some components of metabolic syndrome worsen the prognosis in cervical cancer. Despite the global implementation of preventive strategies against Human Papilloma Virus (HPV) infection, the incidence of invasive cervical cancer rose by nearly 1.3-fold, from 471,000 annual cases in 2000 to 604,000 cases in 2020. With over 340,000 deaths annually, cervical cancer is the fourth leading cause of cancer mortality in women globally. There is a need to understand other factors besides HPV such as metabolic syndrome (MetS) that potentially influence the onset and progression of cervical cancer. In this narrative review, we describe evidence showing that Metabolic syndrome (MetS) increases the risk for cervical cancer and worsens its prognosis. Combined screening for MetS and cervical cancer has potential to significantly reduce morbidity and mortality in women with cervical cancer.