Microvessel derived endothelial cell isolation, adherence, and monolayer formation for vascular grafts

MVECs can be isolated from animal and human fat in quantities and in a pure enough form to produce a cell-lined vascular graft. In animal studies grafts treated with these cells are associated with prolongation of graft patency. In human implants definitive expression factor VIII related antigen cel...

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Bibliographic Details
Published inJournal of vascular surgery Vol. 13; no. 5; pp. 733 - 734
Main Authors Jarrell, Bruce E., Williams, Stuart K.
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.05.1991
Subjects
Animals
Blood Vessel Prosthesis
Capillaries - cytology
Cell Adhesion
Cell Separation
Endothelium, Vascular - cytology
Endothelium, Vascular - transplantation
Graft Occlusion, Vascular - prevention & control
Humans
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Summary:MVECs can be isolated from animal and human fat in quantities and in a pure enough form to produce a cell-lined vascular graft. In animal studies grafts treated with these cells are associated with prolongation of graft patency. In human implants definitive expression factor VIII related antigen cells has been performed on an MVEC treated graft at 9 months. Further studies will be necessary to provide further insight into the healing and long-term behavior of these grafts, both with respect to the thrombogenicity of the surface as well as the influence on anastomotic hyperplasia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0741-5214
1097-6809
DOI:10.1016/0741-5214(91)90366-3