The Development of Neurobehavioral Toxicology in China: The 1994 Hänninen Lecture

With the rapid growth of industrialization in China, occupational and environmental exposure to chemicals has increased in frequency and in types of chemical exposures. A growing number of Chinese researchers are showing a special interest in exploring the effects of chemicals on the central nervous...

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Bibliographic Details
Published inEnvironmental research Vol. 73; no. 1-2; pp. 9 - 17
Main Authors Liang, Y.X., Chen, Z.Q., Wang, C., Tang, H.W., Yang, H.G.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier Inc 01.04.1997
Elsevier
Subjects
Adolescent
Adult
Age Factors
Behavior - drug effects
Biological and medical sciences
Biomarkers
Educational Status
Environmental Pollutants - poisoning
Female
General aspects. Methods
Humans
Lead Poisoning - metabolism
Lead Poisoning - physiopathology
Male
Medical sciences
Middle Aged
Nervous System - drug effects
Nervous System - physiopathology
Neuropsychological Tests
Neurotransmitter Agents - metabolism
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Sex Factors
Toxicology
Asia
China
Human
Nervous system diseases
Toxicity
Chemical compound
Central nervous system
Neuropsychological test
Biological marker
Occupational exposure
Biological monitoring
Pollutant
Environment
Computer aid
Public health
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Summary:With the rapid growth of industrialization in China, occupational and environmental exposure to chemicals has increased in frequency and in types of chemical exposures. A growing number of Chinese researchers are showing a special interest in exploring the effects of chemicals on the central nervous system. This paper presents a comprehensive review of neurobehavioral toxicology in China. It describes research into the “reference values” of the Neurobehavioral Core Test Battery (NCTB) tests, the development and improvement of the computer-administered Chinese version of the Neurobehavioral Evaluation System (NES-C), and exploration of related biomarkers. On the basis of this research, baseline data for the reference values for six subtests of the NCTB were preliminarily recommended. The upgraded NES-C2 has proven to possess higher stability and validity compared with the previous version, NES-C. Biomarkers derived from the changes in levels of neurotransmitter metabolites might be used as supplementary biomarkers of Pb-induced neurotoxicity.
ISSN:0013-9351
1096-0953
DOI:10.1006/enrs.1997.3739