Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside

Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complicat...

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Published inDiabetes & metabolic syndrome clinical research & reviews Vol. 13; no. 2; pp. 1117 - 1122
Main Authors de Oliveira, Amanda Almeida, Davis, Destiny, Nunes, Kenia Pedrosa
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.03.2019
Subjects
Animals
Humans
Metabolic syndrome
Metabolic Syndrome - physiopathology
Metabolic Syndrome - therapy
NLRs
Receptors, Pattern Recognition - metabolism
Signal Transduction
Therapeutic targets
TLRs
NLRs
Metabolic syndrome
TLRs
Therapeutic targets
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Summary:Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complications associated with this condition. Therefore, to evolve therapeutic strategies targeting PRRs might be an imperative approach to avoid the development of further complications in human subjects. In this work, we discuss the understanding regarding the roles of PRRs in the pathways of MetS to further describe potential advancements made to target these receptors within this pathology.
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ISSN:1871-4021
1878-0334
1878-0334
DOI:10.1016/j.dsx.2019.01.012