RNAi turns 25:contributions and challenges in insect science

Since its discovery in 1998, RNA interference (RNAi), a Nobel prize-winning technology, made significant contributions to advances in biology because of its ability to mediate the knockdown of specific target genes. RNAi applications in medicine and agriculture have been explored with mixed success....

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Bibliographic Details
Published inFrontiers in insect science Vol. 3; p. 1209478
Main Author Palli, Subba Reddy
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.10.2023
Subjects
Insect Science
dsRNA
endosomes
RNAi
nanoparticles
pests
insects
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ISSN2673-8600
2673-8600
DOI10.3389/finsc.2023.1209478

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Summary:Since its discovery in 1998, RNA interference (RNAi), a Nobel prize-winning technology, made significant contributions to advances in biology because of its ability to mediate the knockdown of specific target genes. RNAi applications in medicine and agriculture have been explored with mixed success. The past 25 years of research on RNAi resulted in advances in our understanding of the mechanisms of its action, target specificity, and differential efficiency among animals and plants. RNAi played a major role in advances in insect biology. Did RNAi technology fully meet insect pest and disease vector management expectations? This review will discuss recent advances in the mechanisms of RNAi and its contributions to insect science. The remaining challenges, including delivery to the target site, differential efficiency, potential resistance development and possible solutions for the widespread use of this technology in insect management.
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Edited by: Aaron D. Gross, Virginia Tech, United States
Reviewed by: Mohammad Mehrabadi, Tarbiat Modares University, Iran; Kris Silver, Kansas State University, United States
ISSN:2673-8600
2673-8600
DOI:10.3389/finsc.2023.1209478