Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis

• Published in: Scientific reports Vol. 5; no. 1; p. 12972
• Main Authors: Niu, Yu-Ming, Du, Xin-Ya, Lu, Ming-Yi, Xu, Qiong-Li, Luo, Jie, Shen, Ming
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 17.08.2015
• Subjects: Asian Continental Ancestry Group - genetics; Cancer; Databases, Factual; Genetic Predisposition to Disease; Head & neck cancer; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - pathology; Humans; Meta-analysis; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Minority & ethnic groups; miRNA; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Sensitivity analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep12972

Molecular epidemiological studies have showed a closer association between microRNA polymorphisms with and head and neck cancer (HNC) risk. But the results of these studies were inconsistent. We performed this meta-analysis to clarify the associations between microRNA polymorphisms and HNC risk. Four electronic databases (PubMed, Embase, CNKI, and Wanfang) were searched. Odds ratios (ORs) with 95% confidence interval (CIs) were calculated to assess the association between microRNA-146a rs2910164 G > C, microRNA-196a2 rs11614913 C > T, microRNA-149 rs2292832 C > T, microRNA-499 rs3746444 A > G polymorphisms and HNC risk. Heterogeneity, publication bias and sensitivity analysis were conducted to guarantee the statistical power. Overall, 11 selected articles involving 16100 subjects were included in this meta-analysis. Significantly increased risk between microRNA-146a rs2910164 G > C polymorphism and HNC risk were observed in Caucasian population (GC vs. GG: OR = 1.31, 95%CI = 1.01-1.68; GC + CC vs. GG: OR = 1.26, 95%CI = 1.02-1.57). For microRNA-196a2 rs11614913 C > T, similarly increased risk were also found in Asian population (T vs. C, OR = 1.14, 95%CI = 1.04-1.25; TT vs. CC, OR = 1.33, 95%CI = 1.09-1.61; CT + TT vs. CC OR = 1.32, 95%CI = 0.99-1.76; TT vs. CC + CT, OR = 1.14, 95%CI = 0.99-1.33). In addition, no significant association was detected between microRNA-149 rs2292832 C > T and microRNA-499 rs3746444 A > G polymorphism and HNC risk. This meta-analysis demonstrates that microRNA polymorphisms are associated with HNC development based on ethnicity diversity.