Detecting the golgi protein 73 of liver cancer with micro cantilever

Golgi protein 73 (GP73) is a potential serum biomarker used in diagnosing human hepatocellular carcinoma (HCC). Compared to alpha-fetoprotein, detection of GP73 is expected to give better sensitivity and specificity and thus offers a better method for diagnosis of HCC at an early stage. In this pape...

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Bibliographic Details
Published inAdvances in natural sciences. Nanoscience and nanotechnology Vol. 5; no. 4; pp. 45016 - 4
Main Authors Le, Thi Thanh Tuyen, Pham, Van Tho, Phan, Thanh Nhat Khoa, Pham, Van Binh, Le, Van Thao, Tong, Duy Hien
Format Journal Article
LanguageEnglish
Published IOP Publishing 01.12.2014
Subjects
AFP
Antibodies
biomarker
Biomarkers
GP73
Human
microcantilever
Nanostructure
Nanotechnology
Proteins
Serums
Silicon nitride
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Summary:Golgi protein 73 (GP73) is a potential serum biomarker used in diagnosing human hepatocellular carcinoma (HCC). Compared to alpha-fetoprotein, detection of GP73 is expected to give better sensitivity and specificity and thus offers a better method for diagnosis of HCC at an early stage. In this paper, silicon nitride microcantilever was used to detect GP73. The cantilever was modified through many steps to contain antibody of GP73. The result shows that the cantilever can be used as a label-free sensor to detect this kind of biomarker.
Bibliography:Vietnam Academy of Science and Technology
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ISSN:2043-6262
2043-6254
2043-6254
2043-6262
DOI:10.1088/2043-6262/5/4/045016