Proteomic profiling reveals a signature for optimizing prognostic prediction in Colon Cancer

• Published in: Journal of Cancer Vol. 12; no. 8; pp. 2199 - 2205
• Main Authors: Shan, Zezhi, Luo, Dakui, Liu, Qi, Cai, Sanjun, Wang, Renjie, Ma, Yanlei, Li, Xinxiang
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2021; Ivyspring International Publisher
• Subjects: Accuracy; Biomarkers; Cancer therapies; Colorectal cancer; Genomes; Growth factors; Kinases; Lymphatic system; Medical prognosis; Metastasis; Multivariate analysis; Proteins; Regression analysis; Research Paper; proteomic profiling; prognosis; colon cancer
• ISSN: 1837-9664; 1837-9664
• DOI: 10.7150/jca.50630

Previous studies developed prognostic signatures largely depended on transcriptome profiles. The purpose of our present study was to develop a proteomic signature to optimize the evaluation of prognosis of colon cancer patients. The proteomic data of colon cancer patient cohorts were downloaded from The Cancer Proteome Atlas (TCPA). Patients were randomized 3:2 to train set and internal validation set. Univariate Cox regression and lasso Cox regression analysis were performed to identify the prognostic proteins. A four-protein signature was developed to divide patients into a high-risk group and low-risk group with significantly different survival outcomes in both train set and internal validation set. Time-dependent receiver-operating characteristic at 1 year demonstrated that the proteomic signature presented more prognostic accuracy [area under curve (AUC = 0.704)] than the American Joint Commission on Cancer tumor-node-metastasis (AJCC-TNM) staging system (AUC = 0.681) in entire set. In conclusion, we developed a proteomic signature which can improve prognostic accuracy of patients with colon cancer and optimize the therapeutic and follow-up strategies.