Rapeseed oil ingestion and exacerbation of hypertension-related conditions in stroke prone spontaneously hypertensive rats

Two groups of 20 stroke prone spontaneously hypertensive rats (SHRSP) at 5 weeks old were fed a diet containing 10 w/w% rapeseed (canola) oil or soybean oil as the only dietary fat, and given drinking water containing 1% NaCl. Life span of the canola oil group (62±2 days) was shorter than that of th...

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Published inToxicology (Amsterdam) Vol. 187; no. 2; pp. 205 - 216
Main Authors Naito, Yukiko, Nagata, Tomoko, Takano, Yuko, Nagatsu, Takashi, Ohara, Naoki
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 03.05.2003
Amsterdam Elsevier Science
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Summary:Two groups of 20 stroke prone spontaneously hypertensive rats (SHRSP) at 5 weeks old were fed a diet containing 10 w/w% rapeseed (canola) oil or soybean oil as the only dietary fat, and given drinking water containing 1% NaCl. Life span of the canola oil group (62±2 days) was shorter than that of the soybean oil group (68±3 days). Stroke-related symptoms were observed in every animal, but the onset of those in the canola oil group, at 47±1 days after starting the administration was earlier than that in the soybean oil group, 52±2 days. Incidence of cerebral hemorrhage was similar in these groups, and no differences were found between lesions of organs in the groups. In another experiment, two groups of ten SHRSP at 5 weeks of age were fed the defatted diet and given canola oil or soybean oil by gavage at 10 w/w% of consumed food for 4 weeks without NaCl loading. After the 4-week administration, mean systolic blood pressure in the canola oil group and the soybean oil group were 233±2 and 223±0.3 mmHg, respectively. Phytosterol levels in both plasma and erythrocyte membranes reflected those contained in the oils ingested. Na +, K +-ATPase activities in the brain, heart and kidney were enhanced in the canola oil group. These results indicate that promotion of hypertension-related deterioration in organs is likely to have relevance to the short life span in the canola oil group. Enhanced Na +, K +-ATPase activity by phytosterols in the oil ingested may play a role in these changes.
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ISSN:0300-483X
1879-3185
DOI:10.1016/S0300-483X(03)00052-0