Spontaneous reduction of iron()porphyrin to iron()porphyrin-CO complex in mouse circulation

Iron( ii / iii )porphyrin/cyclodextrin inclusion complexes serve as hemoprotein models in vivo . Here we showed the iron( iii )porphyrin complex to be spontaneously reduced to its iron( ii ) state in mouse circulation. The reduced complex bound endogenous CO from carboxyhemoglobin, which was followe...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 59; no. 41; pp. 6211 - 6214
Main Authors Noguchi, Masataka, Mao, Qiyue, Nakagami, Atsuki, Kitagishi, Hiroaki
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 18.05.2023
Subjects
Animals
Carboxyhemoglobin
Cyclodextrins
Heme
Hemeproteins
Inclusion complexes
Iron
Iron - metabolism
Mice
Porphyrins
Reduction
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Summary:Iron( ii / iii )porphyrin/cyclodextrin inclusion complexes serve as hemoprotein models in vivo . Here we showed the iron( iii )porphyrin complex to be spontaneously reduced to its iron( ii ) state in mouse circulation. The reduced complex bound endogenous CO from carboxyhemoglobin, which was followed by urinary excretion. The natural reduction system was found to be effective for synthetic heme-model compounds. In mice, an iron( iii )porphyrin is internally reduced to its iron( ii ) state during circulation and excreted with CO in the urine.
Bibliography:Electronic supplementary information (ESI) available: Experimental section and Fig. S1. See DOI
https://doi.org/10.1039/d3cc00420a
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00420a