Leptin: Adiponectin ratio discriminated the risk of metabolic syndrome better than adiponectin and leptin in Southwest Nigeria

• Published in: Diabetes & metabolic syndrome clinical research & reviews Vol. 13; no. 3; pp. 1845 - 1849
• Main Authors: Adejumo, Esther Ngozi, Adejumo, Olusola Adedeji, Azenabor, Alfred, Ekun, Ayodele Oloruntoba, Enitan, Seyi Samson, Adebola, Olayimika Kehinde, Ogundahunsi, Omobolanle Abioye
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2019
• Subjects: Adiponectin; Adiponectin - blood; Adult; Biomarkers - blood; Body Mass Index; Case-Control Studies; Female; Follow-Up Studies; Humans; Leptin; Leptin - blood; Leptin:Adiponectin ratio; Male; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Metabolic Syndrome - epidemiology; Middle Aged; Nigeria; Nigeria - epidemiology; Prognosis; Nigeria; Metabolic syndrome; Nigeria; Leptin:Adiponectin ratio; Leptin; Adiponectin
• ISSN: 1871-4021; 1878-0334; 1878-0334
• DOI: 10.1016/j.dsx.2019.04.008

To assess the ability of leptin, adiponectin and leptin: adiponectin ratio (LAR) to discriminate apparently healthy subjects with metabolic syndrome in Southwest Nigeria. One hundred and twenty three subjects with metabolic syndrome (cases) were age matched with 123 subjects without metabolic syndrome. The serum adiponectin and leptin levels were measured using standard procedures. The ability of serum adiponectin, leptin and LAR to discriminate metabolic syndrome and its components were determined using the receiver operating curve and linear regression. The median age of the cases (49 IQR 42, 56 years) was not significantly different from the controls (48 IQR 39, 56 years) p = 0.252. The adiponectin levels was reduced with increasing number of the components of metabolic syndrome from 11.6 (IQR 9.6, 13.5) among subjects without any component of metabolic syndrome to 6.5 (IQR 5.7, 7.7) in subjects with more than three components of metabolic syndrome. For leptin and LAR, the values increased with increasing components (p < 0.001). LAR (AUC 0.960) discriminated metabolic syndrome better than adiponectin (AUC 0.865) and leptin (AUC = 0.918) in males and females (LAR AUC = 0.966, adiponectin AUC = 0.888, leptin AUC = 0.929). LAR had better ability to discriminate the risk of metabolic syndrome than adiponectin and leptin alone in males and females among apparently healthy subjects from Southwest Nigeria.