Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone

A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI as a catalyst. The cycloaddition reaction has b...

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Bibliographic Details
Published inJournal of chemistry Vol. 2021; pp. 1 - 10
Main Authors Aarjane, Mohammed, Slassi, Siham, Tazi, Bouchra, Amine, Amina
Format Journal Article
LanguageEnglish
Published New York Hindawi 2021
Hindawi Limited
Wiley
Subjects
Acids
Azide
Cancer
Cycloaddition
NMR
Nuclear magnetic resonance
Triazoles
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Summary:A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI as a catalyst. The cycloaddition reaction has been performed using conventional as well as microwave-assisted methods. Microwave-assisted synthesis caused a significant reduction in the reaction times and improvement in the yields of all the synthesized compounds compared with the conventional method. The structure of the 1,4-disubstituted 1,2,3-triazoles has been elucidated by IR, HRMS, 1H-NMR, 13C-NMR, and 2D NMR (1H-13C HMBC, 1H-1H COSY, and 1H-1H NOESY) spectroscopies.
ISSN:2090-9063
2090-9071
DOI:10.1155/2021/5540173