How alternative splicing changes the properties of plant proteins

Most plant primary transcripts undergo alternative splicing (AS), and its impact on protein diversity is a subject of intensive investigation. Several studies have uncovered various mechanisms of how particular protein splice isoforms operate. However, the common principles behind the AS effects on...

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Bibliographic Details
Published inQuantitative plant biology Vol. 3; p. e14
Main Authors Kashkan, Ivan, Timofeyenko, Ksenia, Růžička, Kamil
Format Journal Article
LanguageEnglish
Published England Cambridge University Press 2022
Subjects
Alternative splicing
Chloroplasts
competitive inhibition
Enzymatic activity
feedback loop
Flowers & plants
Isoforms
Localization
Mutation
network motifs
plant development
Proteins
Review
RNA processing
Splicing
feedback loop
plant development
network motifs
alternative splicing
RNA processing
competitive inhibition
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Summary:Most plant primary transcripts undergo alternative splicing (AS), and its impact on protein diversity is a subject of intensive investigation. Several studies have uncovered various mechanisms of how particular protein splice isoforms operate. However, the common principles behind the AS effects on protein function in plants have rarely been surveyed. Here, on the selected examples, we highlight diverse tissue expression patterns, subcellular localization, enzymatic activities, abilities to bind other molecules and other relevant features. We describe how the protein isoforms mutually interact to underline their intriguing roles in altering the functionality of protein complexes. Moreover, we also discuss the known cases when these interactions have been placed inside the autoregulatory loops. This review is particularly intended for plant cell and developmental biologists who would like to gain inspiration on how the splice variants encoded by their genes of interest may coordinately work.
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I.K. and K.T. contributed equally to this work.
ISSN:2632-8828
2632-8828
DOI:10.1017/qpb.2022.9