Fe-Catalyzed enaminone synthesis from ketones and amines

We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions. A novel Fe-cat...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 17; no. 28; pp. 6753 - 6756
Main Authors Wu, Wenfeng, Wang, Zhuxian, Shen, Qun, Liu, Qiang, Chen, Huoji
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 17.07.2019
Royal Society of Chemistry
Subjects
Alkenes
Amines
Chemical synthesis
Chemistry
Chemistry, Organic
Iron
Ketones
NMR
Nuclear magnetic resonance
Physical Sciences
Science & Technology
Substrates
C(SP)-H BOND FUNCTIONALIZATION
CASCADE REACTIONS
SATURATED KETONES
DERIVATIVES
DIRECT BETA-ARYLATION
INSIGHTS
Online AccessGet full text

Cover

More Information
Summary:We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions. A novel Fe-catalyzed β-functionalization of ketones with amines for constructing enaminones has been demonstrated.
Bibliography:Electronic supplementary information (ESI) available: Experimental section, characterization of all compounds, Fig. S1, copies of
1
H and
13
10.1039/c9ob01137d
C NMR spectra for all target compounds. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob01137d